Dance Dance Revolution
From The Big Bang Theory Wiki
One of the games Sheldon and Leonard have for their video game console.
Related quote:
Howard: (finishing a round of Dance Dance Revolution) Grab a napkin, homey, you just got served.
Leonard: That’s fine, you win. (walks away)
Howard (to Sheldon): What’s his problem?
Sheldon: His imaginary girlfriend broke up with him.
Howard: Been there!
