Secret Agent Laser Obstacle Chess
From The Big Bang Theory Wiki
A variation on the game of chess played by the guys in their apartment. They set up a grid of green lasers which will trigger an alarm if interrupted. A player must spray disinfectant spray to make the lasers visible, then attempt to contort themselves around the beams and make it safely to the other side, whereupon they are allowed to make a move on the chess board.
Howard suggests a variation involving women: Laser Obstacle Strip Chess.
Later, they guys play another variation on the game: Secret Agent Laser Obstacle Lunch. In this version, making it through the beams allows a player to eat a slice of pizza. This iteration of the game apparently goes too far in Leonard's estimation. He says it's "just stupid".